Cancer Stem Cells
Cancer stem cells (CSC's) are subpopulations of cancer cells that can self-recharge, create different cells in the tumor mass, and manage tumorigenesis. Cancer specialists guess that tumors emerge from cancer stem cells that begin because of mutational hits on ordinary stem cells, by the change of confined forebear cells or even the separated cells that get a self-restoring limit. Cancer stem cells drive tumor movement, repeat after chemotherapy medicines, and have as of late moved toward becoming focuses for cancer stem cell treatments. Since both ordinary stem cells and cancer cells have the capacity to self-recharge, numerous pathways that are traditionally connected with cancer are likewise associated with the control of typical stem cell advancement including Notch, Wnt, Shh and established pluripotency translation factor pathways.
- Stem cell mutation
- De-differentiation
- Metastasis
- CSC-specific agents
- miRNA expression
