Viral hepatitis is a serious health problem worldwide. However, the reduction in morbidity and mortality achieved by vaccination against hepatitis A and B has been an important contribution to the overall reduction in vaccine-preventable infectious diseases. We investigate infection transmission, vaccine development, and post-vaccination effects against hepatitis A and B viruses. We also study efforts to reach the 350 million hepatitis B-infected people worldwide with a hepatitis D vaccine. Given the lack of a hepatitis C vaccine, we review the many challenges in developing a hepatitis C vaccine, as well as current and previous vaccine research. There is currently no FDA-approved Hepatitis E vaccine, so we present information about vaccines available in other parts of the world. Finally, we discuss the current challenges and questions facing the future treatment of all Hepatitis infections. Efforts continue to be made to significantly reduce the morbidity and mortality associated with these serious liver infections.